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Nat Rev Neurosci 7 : 4153

10.1016/s1875-5364(20)30073-x 206 ZhouY.HuangY.YeW.ChenZ.YuanZ

Clinical studies have demonstrated a significant positive correlation between serum copper levels and HIF-1 levels in patients with liver cancer, suggesting that copper accumulation may lead to the activation of HIF-1 and promote the development of liver cancer (103)