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Xu H, Luo R, Dong L et al (2022) pH/ROS dual-sensitive and chondroitin sulfate wrapped poly (-amino ester)-SA-PAPE copolymer nanoparticles for macrophage-targeted oral therapy for ulcerative colitis

Feb 2024;44(2):513-521

Because it is largely free of those binding proteins, the analog stays active far longer than native IGF-1 a substantially extended half-life and more sustained systemic exposure