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Hello everyone Im so pleased I found this page Sorry if this is too much ..but Im Thinking to introduce myself I need to write some of my life (first time on a forum ), I have always been extremely active only way I can explain is I will find something to do rather than not, in every aspect of my life having episodes of ibs not a diagnosed type and lots of health problems restless legs unexplained itching , one time when I was 30yrs struggling to walk for two weeks ,endoscopies few times through my life they found hiatus hernia and I even had a 2 week isolation stay in hospital when I was approx 6years old no formal diagnosis it was explained as issues with stomach numerous tests started again 8-10 yrs ago after episode of iron deficiency anemia I struggled swallowing i lost rapid weight over a month and climbing stairs extremely difficult with palpitations and breathlessness and after another endoscopy diagnosis (there words) it must have been a virus went on to have full hysterectomy approx 5yrs ago

Immunol Allergy Clinics North America

Ophthalmology 1981

In animal models, knock-out of clock genes such as period circadian regulator 1 and 2 (Per1, Per2), brain and muscle Arnt-like protein-1 (Bmal1) led to infertility in mice (64)