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Deficiencies in the Nrf2 factor not only increase susceptibility to oxidative stress but also prevent melanocytes from maintaining proper redox balance, leading to sustained ROS production and greater melanocyte vulnerability 113

IL-4 induce MCP-1 gene expression by dramatically increasing the transcription factor, signal transducers and activators of transcription 1 (STAT1 ) DNA binding activity, an effect that was attenuated by PDTC

The beneficial effects of Se supplementation may stem from its presence in the structure of several selenoenzymes

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