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As environmental factors, gut microbiota performs critical functions in the pathogenesis of AS through various mechanisms, including interacting with genes, enhancing intestinal permeability, activating the gut mucosa immune system, and affecting the intestinal microbiota metabolites

It decreases basal corticotropin levels and blocks cortisol release, which explains its stress-reducing properties

J Biol Chem 284:1160111612 Chung WJ, Sontheimer H (2009) Sulfasalazine inhibits the growth of primary brain tumors independent of nuclear factor-B

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