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The negatively charged residues D315, D323, and D333 likely form a catalytic loop (8-8) that directly interacts with the hydroxyl groups of ribose by hydrogen bonding (Supplementary Fig

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10.1093/aje/kwy193 13 FisherB

Non-differential misclassification was therefore likely, probably leading to bias towards the null.] The only study reporting on the interaction between sex and ASB consumption (McCullough et al., 2022) did not find evidence of an effect of sex on the association ( P for interaction, 0.145)