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Adult liver flukes show similar morphology among the three species, characterized by flattened and lance shape (11, 19) (Table 1)

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This review summarizes the primary mechanism of GC chemoresistacne and focuses on mechanisms of enhancing chemotherapy sensitivity and reversing drug resistance in TCM from the standpoint of the signaling pathways, which include PI3K/Akt, NF-kB, MAPK, P53, STAT3, TGF-, Nrf2, and Wnt/b-catenin, thereby affecting various biological processes, such as cell cycle, cell proliferation, migration, apoptosis, autophagy, ferroptosis, TME, EMT, DNA damage repair, and cell stemness ( Table 1 )

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