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Cells were blocked for 5 min with 3% BSA/PBS followed by incubation of corresponding primary antibody in 3% BSA/PBS for 1h at room temperature

Subsequent in vitro and in vivo dissolution studies demonstrated a marked enhancement in the dissolution rate and bioavailability of drugs encapsulated within SOR-P188-CSD formulations compared to the active pharmaceutical ingredient (API)

This includes functional annotation of crucial metabolites, proteins and genes, pathway enrichment and Gene Ontology analysis (Khan et al., 2023a)

TLR4 recognizes lipopolysaccharides (LPS) from Gram-negative bacteria and contributes to hepatocellular injury, insulin resistance, and NASH development