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HSA contains three domains (I, II and III) each consisting of two subdomains (A and B) with common structural motifs

A recent study has revealed that ERS can increase the levels of unsaturated triacylglycerol precursors and reduce lipid droplet formation, leading to tubular injury and fibrosis in renal proximal tubular cell lines and STZ-induced diabetic mouse kidneys (80)

In GMCs, CHOP is linked to the expression of collagen-related factors such as Col1a2, TGF-1, and Col1a4, which promote the synthesis of collagen in DKD