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54 However, previous studies have also demonstrated that MSCs are capable of secreting anti-inflammatory cytokines, anticatabolic mediators, and growth factors when cultured under IDD-like conditions both in vitro 55 and ex vivo, 56 hence demonstrating an immunomodulatory effect on resident IVD cells

Next, we evaluated the brain metabolomic and transcriptional profiles of Tbx1 +/ and WT mice treated postnatally with vB12 or PBS as described above (Group 3 in Fig S1C, Tables S1 and S2)

In the presence of GSH, MnO is converted to Mn 2 , leading to fluorescence recovery that correlates with GSH concentration [94]

Mechanistic evidence relies heavily on animal studies (e.g., mouse neurotransmitter experiments) with insufficient large-scale human randomized controlled trials (RCTs) to confirm causality