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JAMA Netw Open 2021;4(12):e2139765-e2139765 Nicolien A van Vliet, Diana van Heemst, Osvaldo P Almeida, Bjrn O Asvold, Carole E Aubert, Jong Bin Bae, Linda E Barnes, Douglas C Bauer, Gerard J Blauw, Carol Brayne, Anne R Cappola, Graziano Ceresini, Hannie C Comijs, Jean-Francois Dartigues, Jean-Marie Degryse, Robin P F Dullaart, Marlise E A van Eersel, Wendy P J den Elzen, Luigi Ferrucci, Howard A Fink, Leon Flicker, Hans J Grabe, Ji Won Han, Catherine Helmer, Martijn Huisman, M Arfan Ikram, Misa Imaizumi, Renate T de Jongh, J Wouter Jukema, Ki Woong Kim, Lewis H Kuller, Oscar L Lopez, Simon P Mooijaart, Jae Hoon Moon, Elisavet Moutzouri, Matthias Nauck, Jim Parle, Robin P Peeters, Mary H Samuels, Carsten O Schmidt, Ulf Schminke, P Eline Slagboom, Eystein Stordal, Bert Vaes, Henry Volzke, Rudi G J Westendorp, Michiko Yamada, Bu B Yeap, Nicolas Rodondi, Jacobijn Gussekloo, Stella Trompet, Thyroid Studies Collaboration Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis

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238 Inhibiting the demethylase activity of FTO with Rhein can sensitize resistant cells to TKIs, downregulate Bcl-2 and MER proto-oncogene, tyrosine kinase (MERTK), thus regulating the PI3K-AKT-mTOR pathway and the Bcl-2 family of proteins, which affects the invasion and apoptosis of cancer cells

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