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[DOI] [PubMed] [Google Scholar] 228.Du M, Yu T, Zhan Q, Li H, Zou Y, Geng M, et al

Obesity-induced epigenetic modifications, particularly those involving the SUV39H1 methyltransferase, JMJD2C/SRC-1 demethylase and SRC-1 acetyltransferase, have the potential to lower the levels of H3K9me2/me3 while simultaneously elevating H3K9 acetylation, which binds to the p66Shc promoter (34)

Further analysis of rat in vivo CL u and in vivo V ssu revealed that the observed improvement in half-life, in cases where it was statistically significant, was achieved despite the increase seen in in vivo CL u (Table S1 and Figure S3)

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