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Accordingly, insulin and counter-insular signals in the liver modulate systemic glycemia primarily by regulating hepatic glucose production and utilization rather than by forcing glucose entry through high-affinity transport

Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A, editors

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Meanwhile, in the outermost layer of the cornea, the epithelial cells possess tight junctions and efflux pumps that promote drug loss either by preventing paracellular drug permeation or inhibiting drug entry into the cell [28]