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Eupalinolide B disrupts the copper homeostasis of pancreatic cancer cells, enhances the accumulation of mitochondrial reactive oxygen species, and collaborates with the copper ion carrier elesclomol to induce cuproptosis [202]

Many enzymes of DNA replication and repair (helicases, nucleases, glycosylases, demethylases) and ribonucleotide reductase use Fe as an indispensable cofactor for functioning (92)