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Bub1 is the kinase responsible for phosphorylation of H2AT120 and H3T3 phosphorylated by Haspin kinase [34, 35]

They actively transport substrates out of cells, performing a detoxification function by excreting substances into the intestinal lumen, bile canaliculi, and renal tubules, thereby protecting the body from exogenous compounds

doi: 10.1016/j.foodchem.2011.09.029 434

Mechanistic studies have shown that oxidative stress further upregulates 5-LOX expression by activating the Nrf2 signaling pathway, forming a vicious cycle of oxidative stress-lipid peroxidation, which leads to impaired humoral immune function and the expansion of myeloid-derived suppressor cells (MDSCs), thereby promoting tumor immune escape (160)