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An increase in activated microglia has been observed in both PD patients and healthy older people, indicating that various triggers might induce a proinflammatory shift with age (57)

Plasma volume and red blood cell mass A measurable expansion of plasma volume already exists at the 6th8th week of gestation and this increase continues up to the 34th36th week of gestation (Reference Hytten21)

PMID: 39485699, DOI: 10.1080/15389588.2024.2373950

Interestingly, ALDH is required for retinoid-driven hematopoietic differentiation in human and mouse HSCs, which suggests that high ALDH expression in stem cells may reflect a more differentiated state 19