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Meanwhile, the ratio of GSR to GPX4 at the protein level was decreased in the A2ARi-treated group compared with the control group (Figure 3I), indicating that the GSSG accumulation upon A2ARi treatment is caused likely by an impaired capacity to recycle GSSG back to GSH

For instance, JAK inhibitors such as baricitinib, tofacitinib, upadacitinib, and ruxolitinib have demonstrated efficacy in clinical settings for managing CS in conditions such as aGVHD, rheumatoid arthritis, sJIA, and systemic lupus erythematosus