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308 Interestingly, low ROS levels can activate mTORC1 through the oxidation of cysteine residues in the mTORC1 complex itself 309 or in RHEB

Animals were exposed to GSH at the L4 stage

Methylmercury is believed to exert its deleterious effects on cellular microtubules via oxidation of tubulin SH, and by alterations due to peroxidative injury

Strategies for better clinical outcomes Given the importance of the lactateNAMPT axis, the combination strategies targeting this pathway could offer improved therapeutic efficacy and reduced toxicity