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DOI: 10.1038/345224a0 Schle, R., Umesono, K., Mangelsdorf, D.J., Bolado, J., Pike, J.W., Evans, R.M

Future studies need to move beyond the linear explanatory framework based on a single metabolite or a single enzyme and systematically clarify, from the perspectives of temporal resolution and tissue niche resolution, the cooperative relationships between different amino acid metabolic axes and the TCA cycle, OXPHOS, and other immunometabolic modules (139)