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Despite the promising therapeutic potential of azelaic acid in melasma, however due to limited water solubility and poor skin permeability, its conventional topical formulations have been fabricated in higher doses (10%20%) to achieve the desired clinical outcome (Sieber and Hegel, 2014

DNA methylation also fulfills important roles in neurogenesis, cell differentiation, neuronal maturation, neuroplasticity, learning and memory, while it is also present and could potentially be involved in the pathogenesis of schizophrenia bipolar disorder [12]

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Deficiency of insulin-like growth factor 1 reduces sensitivity to aging-associated cardiomyocyte dysfunction