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Papaioannou, Alexandra

Abstract Friedreichs ataxia (FRDA) is a rare early-onset degenerative disease that affects both the central and peripheral nervous systems, and other extraneural tissues, mainly the heart and endocrine pancreas

The characteristics like high hydrogen acceptor bonds, higher lipophilicity, presence of more than one aromatic ring and higher molecular weight structure increase the probability of drug as a P-gp substrate