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, 60 (Suppl 5), 7176

Mammalian NAD + Biosynthesis Mammalian cells can meet their NAD + requirements through multiple NAD + -generating metabolic pathways that start from either vitamin B3 or from the essential amino acid tryptophan (Figure 1)

In vitro treatment of CD38-overexpressing CHO cells (CHO-mCD38) with Ab68, but not Ab69, significantly increased both cellular NAD + levels and Sirt1 and Sirt3 deacetylase activity (Fig