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In rodent models of T1D, intestinal permeability or the leakiness of the gut has been studied by measuring the amount of disaccharides and monosaccharides in the urine following their oral administration

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Additionally, rare loss-of-function germline mutations of Kelch-like ECH-associated protein 1 (KEAP1) could be detected in nodular goitre leading to Nrf2 pathway activation that favours transcription of cytoprotective and antioxidant enzymes (92)