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By using the passive and/or active strategies for BBB regulation and crossing in a controlled and non-invasive manner, various drug delivery systems are engineered to facilitate the brain-targeted delivery of specific therapeutics including small-molecule drugs, proteins, genes, and other biopharmaceutics

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The second model is the Cys-sensor-independent mechanism, where KEAP1 function is hindered by proteinprotein interactions rather than being dependent on changes in Cys residues

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