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In conjunction with cytochrome P-450, flavocoenzymes also participate in the metabolism of drugs and toxins (4)

319,321 Collectively, the ability of HSP70 and HSP90 to engage multiple aggregation-prone client proteins across distinct NDDs underscores their central role in neuronal proteostasis and highlights their broad therapeutic potential

and in another hand, the liver wood excessively restricts the spleen soil, the damaged spleen soil fails to control the kidney water, thus forming edema

Of note, GLS1 inhibition causes an elevation of the ROS level and induces GPT2 expression via ATF4, which again implies the importance of ATF4-mediated metabolic adaption during glutamine starvation