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Once reconstituted, store at 28C and use within 812 weeks

[13] DSS Model Results : Weight loss significantly reduced at day 8 Myeloperoxidase activity (neutrophil marker) dropped 50% Prevented colon weight increase and length decrease IL-6 and IL-12 mRNA expression significantly reduced Histology showed less inflammation, reduced cell damage, fewer inflammatory cells in tissue layers TNBS Model Results (more acute inflammation): Weight loss reduced within 1-2 days post-TNBS Colonic MPO activity decreased 30% Prevented TNBS-induced colon shortening Broad cytokine suppression: IL-1, IL-6, TNF-, IFN- mRNA all reduced KPV didnt affect inflammatory markers in healthy mice

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Materialien und Methoden In jeder Ratte wurden zwei sterile Schwmme (1 cm 1 cm 0,25 cm (V = 0,25 ml)) mit den gleichen Mengen an NaBPC157 (Lsung 50 g, 10 g, 10 ng/ml) oder den Referenzmitteln, Cimetidin (10 mg, 100 mg, 500 mg/ml), Ranitidin (2,5 mg, 25 mg, 250 mg/ml), Famotidin (10 mg, 50 mg, 100 mg/ml) und Sucralfat (1 mg, 5 mg, 10 mg/ml), subkutan in der Lumbalregion implantiert