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The few available human studies are small, unblinded, and often conducted by clinics with a stake in the outcome

For some compounds, the substituent groups were placed at incorrect positions

Matsuzawa noted that the major difference in pathologies observed was increased septicemia in mice from the conventionally housed heme/GI group and later appearance of diarrhea in the GI group

These therapies aim to enhance WL and improve metabolic outcomes by engaging multiple hormonal pathways, with preclinical and early-phase clinical trials supporting their potential as next-generation obesity treatments [16,17,18,19,20,21,22,23]