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Potential therapeutic benefit of low dose naltrexone in myalgic encephalomyelitis/chronic fatigue syndrome: role of transient receptor potential melastatin 3 ion channels in pathophysiology and treatment

Elevation in Glu has been observed in white matter lesions but not in normal appearing white matter [41] while in the hippocampus, a depletion in Glu and Glx was measured [40], which was in turn shown to be associated with visual and verbal memory impairment