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The ability of G/D-CuP to scavenge reactive oxygen species (ROS) was evaluated by conducting Fenton-like reactions where hydrogen peroxide (H 2 O 2 ) generates reactive hydroxyl radicals (OH) with the help of metal catalysts, leading to significant oxidative harm 65

These platforms improve water solubility and cell permeability, optimize the pharmacokinetic characteristics of PROTAC, and promote selective localization in tumor tissue through passive or active targeting strategies, thus significantly enhancing treatment selectivity and treatment window [41,42,43,44]

8-OHdG can mispair with adenine during DNA replication, leading to G to T transversions

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