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The expression levels of pro-inflammatory cytokines were also significantly reduced, and the results overall suggest that Grx1-regulated S-glutathionylation in macrophages plays a protective role in acute lung injury (Figure 2)

This multitiered defence system comprises an endogenous antioxidant enzyme system (e.g., SOD/CAT/GPx) and small-molecule free radical scavengers such as vitamin C/E and -carotene, which are supported by trace elements such as selenium and zinc, collectively maintaining redox homeostasis [18]