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Changes have also been noted in higher brain centres, including reduced connectivity between the thalamus and cortex 129 and structural changes, such as a greater reduction in thalamic grey matter volume, in patients with painful diabetic neuropathy compared with those with painless diabetic neuropathy 130

The generation of NADPH, mainly through the pentose phosphate pathway, is intricately linked to the metabolic state of NAD + /NADH, underscoring the interdependence of these redox couples in maintaining cellular health [11, 12]

Plasma levodopa metabolites, DOPAC and dopamine, showed a statistically non-significant upward trend over 3 days in the KD group compared to the standard diet group