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BMC Neurosci 13:113

It can directly bind to MEK1/2, thereby enhancing its kinase activity and promoting the activation of the ERK signaling pathway, which subsequently affects cell proliferation and survival [54]

High Ratio of Membrane Surface Area to Cytoplasmic Volume: Neurons have a large surface area relative to their cytoplasmic volume, which increases their exposure to extracellular oxidizing agents and makes them more susceptible to oxidative damage