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Intradiscal pressure stretches the AF and supports the endplate during axial compression and is hence a primary determinant of disc height and stiffness (Vergroesen et al., 2014

Mechanism: Removes pro-aging plasma factors and resets protein composition

Oxidative stress-induced mitochondrial fission has been implicated in RGC degeneration, with the loss of proteins such as AKAP1 leading to Drp1-mediated mitochondrial fission, increased ROS production, and diminished ATP synthesis, further contributing to RGC death (127, 128)

When addressing MS fatigue, it is crucial to assess how effectively other symptoms related to MS, such as neurogenic bladder, spasticity, depression, and anxiety, are treated, since these can worsen fatigue