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Estrogenic activity of 7-hydroxymatairesinol potassium acetate (HMR/lignan) from Norway spruce ( Picea abies ) knots and of its active metabolite enterolactone in MCF-7 cells

doi: 10.1016/j.pharmthera.2013.09.006

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Neonates are especially vulnerable due to renal immaturity, altered volume of distribution, and incomplete blood-labyrinth barrier development, which together increase both drug accumulation and cochlear susceptibility