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Under normal O 2 concentrations, O 2 atoms are inserted into specific proline residues of HIFs (P402/P564 of HIF-1 and P405/P531 of HIF-2) by PHDs

S11A), and J10 showed significantly lower cytotoxicity compared to RK-33 (Fig

References Mitchell, P

The structure of KatG has been determined by X-ray crystallography [268] or cryo-EM [269], and its structure is similar to peroxidases in many bacteria and plants (Fig