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Description

In contrast to apoptosis and necrosis, ferroptosis is characterized by extensive damage to membrane lipids and is intricately associated with mitochondrial metabolic dysfunctions (38)

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MPP-modified DOX significantly enhances drug accumulation in mitochondria by 11.6 fold, resulting in a significant increase in ROS generation and a decrease in the production of ATP that can inhibit drug efflux and the growth of drug-resistant cancer cells (174)