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While the drug initially showed promise in a Phase 2 study, a large Phase 3 trial failed to meet its primary endpoint, raising major doubts about efficacy.24 No trials of TUDCA alone have shown clear clinical benefit in ALS, and regulatory approvals for the combo have already been withdrawn in the U.S

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Anti-TL1A Antibody PF-06480605 Safety and Efficacy for Ulcerative Colitis: A Phase 2a Single-Arm Study

The characteristics of subjects were similar across the treatment sequences: the mean age range was 24.2-38.0 years, mean weight 65.0-76.5 kg and mean BMI 23.0-24.8 kg/m 2 , and the number of subjects per sequence ranged between 1 and 4