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2) Angiogenesis, because IGF-I is known to exert significant pro-angiogenic effects, inducing proliferation of microvascular endothelial cells in culture through HIF-1 and VEGF[291]

In Kazakhstan, the rehabilitation of L-C19 patients is provided mainly in hospitals, particularly for those with severe manifestations of L-C19 symptoms that include immune deficiency conditions, cognitive disorders, progression of atherosclerosis and exacerbation of hypertension (209)