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Oxidative stress can increase as a result of illness, environmental toxins, poor diet and other lifestyle factors

Glutathione homoeostasis in our cells breaks down as we age and in many health conditions

Curr Pharm Des 10:24632475 Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL (2009) Glutathione dysregulation and the etiology and progression of human diseases