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This has important clinical consequences, such as the lack of biological markers [7] and the hindered development of targeted pharmacological treatments

575 In SAMP8 mice, salidroside upregulates SLC7A11 and GPX4 protein expression through activating Nrf2/GPX4 axis, reduces iron deposition and ACSL4 protein expression, thereby inhibiting ferroptosis and A accumulation, and alleviating cognitive impairment

Diabetes (2014) 64(1):3648

Nevertheless, parkins contribution to H 2 O 2 reduction in the cytosol is unmasked under the following conditions: (i) in the presence of redox stressors, either due to a second genetic hit in mice (Figs