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Daratumumab in combination with lenalidomide plus dexamethasone induces clonality increase and t-cell expansion: results from a phase 3 randomized study (POLLUX)

Lutz and coworkers could establish that the antigenic site preexists in band 3 protein, but becomes accessible for NAb binding upon band 3 clusterization e.g., on spectrin-free vesicles in which band 3 is laterally mobile