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Brain Res 537:298302

Collectively, the scientific data on mitragynine and 7-hydroxymitragynine suggest that kratom tea might indeed be an effective alternative to opioids against pain

Ashmarin, I.P., Nezavibatko, V.N., Myasoedov, N.F., Kamensky, A.A., Grivennikov, I.A., Ponomareva-Stepnaya, M.A., Andreeva, L.A., Kaplan, A.Y., Koshelev, V.B., and Ryasina, T.V., Zh

Autophagy dysregulation is involved in the pathophysiology of DKD by increasing ROS production, mediating inflammatory responses and inducing renal cell damage and apoptosis (116, 117)