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Deficiency in TNSALP leads to hypophosphatasia (HPP), an inborn error of metabolism characterized by epileptic seizures in the most severe cases, caused by abnormal metabolism of pyridoxal-5-phosphate (the predominant form of vitamin B6) and by hypomineralization of the skeleton and teeth featuring rickets and early loss of teeth in children or osteomalacia and dental problems in adults caused by accumulation of inorganic pyrophosphate (PPi) [57]

Although the overall interactions look similar there are a few differences in the strengths of the interactions

In addition, we found that among the infiltrated cells in the perineural areas that positively expressed the Schwann cell marker S-100, GDNF, and BDNF, about 80% of them were exogenous human cells as presented by the expression of human nuclei (Fig

J Pers Med 10(3):112 Agosti E et al (2023) Tumor microenvironment and glioblastoma cell interplay as promoters of therapeutic resistance