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In primary human keratinocytes used as a model of inflammatory skin disease and psoriasis, NAC attenuates the IFN--induced production of cytokines, suggesting that NAC should be considered as part of effective therapy for the treatment of inflammatory skin diseases, including psoriasis [150]

Step-by-step: 1) Collect genetics and baseline labs

They help make red blood cells

What they found: Favorable safety profile , no serious adverse events at doses up to 100 g/kg Preliminary efficacy signals positive The program stopped before Phase 3 for unknown commercial reasons (the program passed through several sponsor rotations and no one ultimately carried it through) Why it matters: These are the only published clinical data in humans that we have