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Drug Dev Ind Pharm (2016) 42(2):31724

Vitamin C (Ascorbic Acid) Function: Collagen synthesis, wound healing, antioxidant Deficiency signs: Scurvy bleeding gums, poor wound healing, fatigue, bruising Vitamin B1 (Thiamine) Function: Energy metabolism, nervous system Deficiency signs: Beriberi neuropathy, heart failure

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In Phase 2 trials involving 338 participants across all doses, 88.8% of patients at the 12mg dose successfully completed the 48-week study despite experiencing side effects