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Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al

Though this ancient gene family has been exhaustively studied in different organisms, still the information available about its sequences and gene organization understates its functional diversity

It has been observed that the anti-cancer effects are associated with an increase of reactive oxygen species (ROS) and reduction of GSH levels

The nuclear factor-erythroid 2-related factor 2 (Nrf2) involves multiple aspects of cellular and organismal defense against oxidative stress, such as detoxification, regulating cell metabolism, and promoting cell proliferation, which is crucial in the pathological mechanism of various diseases