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25 Patients diagnosed with vitamin B 12 deficiency whose history and physical examination do not suggest an obvious dietary or malabsorptive etiology should be tested for pernicious anemia with anti-intrinsic factor antibodies (positive predictive value = 95%), particularly if other autoimmune disorders are present

Less threatening reaction to B1 include anxiety, pruritus, respiratory distress, nausea, abdominal pain

Chihara, K., et al (2006)

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