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389,390,391 Environmental toxins and neurodegenerative disorders Exposure to various types of environmental toxins including trace metals as just discussed, but also pesticides such as organophosphates, substances of abuse such as methamphetamine, organic solvents, air pollutants, and others are increasingly recognised as risk factors in neurodegenerative disorders such as PD and others

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Because the methyl groups (CH 3 ) are projected in the major groove of the DNA, they can block transcription factors, preventing the recognition of the target sequence