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Future studies should incorporate mechanism-relevant biological markers, including serum BDNF to index neurotrophic signaling, inflammatory markers such as CRP and IL-6, measures of HPA-axis activity such as the cortisol awakening response, and neuroimaging markers (e.g., fMRI-based assessments of hippocampal connectivity), to more precisely characterize treatment response and patient stratification

By providing exogenous pyridoxine that is readily converted to PLP, the injection corrects the coenzyme deficiency and reactivates these metabolic pathways

Oncotarget 9 , 72047218 (2017)

Are there non-stimulant alternatives if Adderall causes too much irritability