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93 Although berberine has been studied and shown to have a high level of safety in human clinical trials, concerns about its long-term use have been raised on the basis of preclinical studies that suggest long-term berberine use, especially at high doses, may impair cellular metabolism in specific types of cells

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The effects of LMP formulation on creatine bioavailability were seen at a dose of 51 mg/kg, corresponding to 500 mg daily in humans

The table summarizes the pharmacokinetic data (mean SD mol/L) after the first dose of levocarnitine and after 8 weeks of levocarnitine therapy